Invitrogen™ BRD7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5100009

Catalog No. PIPA5100009

Description

Antibody detects endogenous levels of total BRD7.

BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.

Specifications

• Antigen: BRD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BRD7
• Gene Alias: 75 kDa bromodomain protein; BP75; BRD7; bromodomain containing 7; bromodomain protein 75 kDa; bromodomain-containing 7; bromodomain-containing 7-like protein; bromodomain-containing protein 7; CELTIX1; NAG4; protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein; Ptpn13ip
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 26992, 29117, 361374
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O88665, Q9NPI1
• Gene Symbols: BRD7
• Immunogen: A synthesized peptide derived from human BRD7(Accession Q9NPI1), corresponding to amino acid residues I185-E235.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov