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  6. Invitrogen™ BRD9 Recombinant Rabbit Monoclonal Antibody (BLR153J)

Invitrogen™ BRD9 Recombinant Rabbit Monoclonal Antibody (BLR153J)
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Catalog No. PIMA544491
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PIMA544491 100 μL
PIMA544492 10 μL
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Catalog No. PIMA544491 Supplier Invitrogen™ Supplier No. MA544491
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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

The BRD9 gene encodes a protein that is a crucial subunit of the SWI/SNF chromatin remodeling complex known as ncBAF (non-canonical BAF complex). As a bromodomain-containing protein, BRD9 acts as an 'epigenetic reader,' selectively recognizing acetyl-lysine marks on histones, which is essential for regulating chromatin structure and gene expression through the recruitment of acetylated transcriptional regulators. It has emerged as a significant player in epigenetic modulation and has been implicated in various cancers, such as cervical and non-small cell lung cancer, due to its over-expression. BRD9 is situated on the 5p arm of chromosome 5 and is a potential target for anticancer therapies, notably in acute myeloid leukemia (AML). Recent studies highlight the development of selective BRD9 inhibitors, indicating its potential for therapeutic targeting. Its role in cancer is linked to its function in transcriptional regulation and its involvement in the mammalian SWI/SNF complex, which is linked to tumor suppression mechanisms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRD9
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR153J
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation BBS with 0.09% sodium azide; pH 8.2
Gene BRD9
Gene Accession No. Q9H8M2
Gene Alias AL022779; Brd9; bromodomain containing 9; bromodomain-containing protein 9; DKFZp434D0711; DKFZp686L0539; FLJ43530; LAVS3040; PRO9856; rhabdomyosarcoma antigen MU-RMS-40.8; sarcoma antigen NY-SAR-29; UNQ3040/PRO9856
Gene Symbols BRD9
Host Species Rabbit
Immunogen Peptide representing a region between residue 547 and the C-terminus (residue 597) of Human Bromodomain-containing protein 9.
Purification Method Purified
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65980
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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