BRE Mouse anti-Human, Mouse, Rat, Clone: 2E5A5, Proteintech

Catalog No.	Quantity
50-173-6787	150 μL

Catalog No. 50-173-6787 Supplier Proteintech Group Inc Supplier No. 663561IG150UL

Description

Mouse Monoclonal Antibody

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Specifications

• Antigen: BRE
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: 2E5A5
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: BABAM2
• Gene Accession No.: Q6P7Q1, Q8K3W0, Q9NXR7
• Gene Alias: BRCA1 A complex subunit BRE, BRCC4, BRCC45, BRE
• Gene Symbols: Babam2
• Host Species: Mouse
• Immunogen: BRE Fusion Protein Ag2256
• Purification Method: Protein A
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 107976, 362704, 9577
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2a