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Invitrogen™ BRE Polyclonal Antibody
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Catalog No. PIPA521656
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100 μL
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PIPA521656 100 μL
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Catalog No. PIPA521656 Supplier Invitrogen™ Supplier No. PA521656
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: HeLa, 293T, A431, C8D30, rat testis. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (85%), Xenopus laevis (91%), Chicken (97%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRE
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene BABAM2
Gene Accession No. Q6P7Q1, Q8K3W0, Q9NXR7
Gene Alias 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex subunit BRE; BRCC4; BRCC45; BRE; bre {ECO:0000312; BRISC and BRCA1-A complex member 2; RGD:735111}
Gene Symbols BABAM2
Host Species Rabbit
Immunogen Recombinant protein fragment contain a sequence corresponding to a region within amino acids 9 and 328 (Q9NXR7) of BRE.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 107976, 362704, 9577
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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