Tocris Bioscience™ Brefeldin A

Description

Disrupts protein translocation to Golgi

Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor (ARF1) to the Golgi apparatus and inhibits GDP-GTP exchange. Can be used to induce autophagy in mammalian cells. Also enhances CRISPR-mediated homology-directed repair (HDR) efficiency ∼2-fold when applied at 100 nM, in human induced pluripotent stem cells (iPSCs). Antifungal.

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Specifications

Chemical Identifiers

• CAS: 20350-15-6
• Molecular Formula: C16H24O4

• Quantity: 5 mg
• Formula Weight: 280.36
• Purity: >98%
• Molecular Weight (g/mol): 280.36
• Chemical Name or Material: 1,6,7,8,9,11 Aβ,12,13,14,14 Aα-Decahydro-1β,13α-dihydroxy-6β-methyl-4 H-cyclopent[f]oxacyclotridecin-4-one

Safety and Handling

Recommended Storage

Store at -20°C