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Invitrogen™ Brevican Monoclonal Antibody (N294A/6), APC
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Catalog No. PIMA545596
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100 μg
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PIMA545596 100 μg
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Catalog No. PIMA545596 Supplier Invitrogen™ Supplier No. MA545596
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Description

Mouse Monoclonal Antibody

1 μg/mL of MA5-45596 was sufficient for detection of Brevican in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 140kDa (and smaller due to proteolytic cleavage). This antibody was formerly sold as clone S294A-6.

Brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult brain. It is a member of the lectican family of aggregating extracellular matrix proteoglycans that bear chondroitin sulfate (CS) chains. It is highly expressed in the central nervous system and is thought to stabilize synapses and inhibit neural plasticity. Brevican is secreted from astrocytes and neurons as a 145 kD core protein that bears up to three, covalently-linked, CS chains. It is also is secreted as a 145 kD core protein without CS chains. When cleaved by extracellular glutamyl endopeptidases, the ADAMTSs, a 55 kD N-terminal fragment is formed that contains the unique C terminal epitope EAMESE.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Brevican
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone N294A/6
Concentration 1 mg/mL
Conjugate APC
Formulation 2.48mM MES, 95.46mM phosphate with 2mM EDTA and no preservative; pH 7.4
Gene Bcan
Gene Accession No. P55068, Q61361, Q96GW7
Gene Alias ALPBRE; Bcan; Behab; Brain-enriched hyaluronan-binding protein; brevican; brevican (brain specific proteoglycan in the aggrecan family); brevican core protein; Chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; CSPG7; UNQ2525/PRO6018
Gene Symbols Bcan
Host Species Mouse
Immunogen Fusion protein amino acids 219-655 of rat Brevican.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12032, 25393, 63827
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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