Invitrogen™ BRIP1 Polyclonal Antibody

Catalog No.	Quantity
PIPA517138	100 μL

Catalog No. PIPA517138 Supplier Invitrogen™ Supplier No. PA517138

Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) is a gene situated on chromosome 17q22, covering 19 exons within its 184-kb coding region to encode a protein containing 1249 amino acids. BRIP1 is integral to the DNA repair processes, specifically through its interaction with the BRCA1 gene, and is involved in the Fanconi anemia complementation group J (FANC J). Mutations in BRIP1 have been identified, playing a role in cancer predisposition with a notable eightfold increased risk for ovarian cancer and associations with cervical cancer risk through its single nucleotide polymorphisms (SNPs). Amplifications and other mutations of BRIP1 are prevalent in a variety of cancers, and its expression involves significant correlations with copy number variations (CNV) and DNA methylation across numerous tumor types. BRIP1's expression is upregulated in certain contexts, which can contribute to cancer progression, as evidenced in the Omani population with breast cancer. These interactions validate its association with DNA damage repair, cell cycle, and metabolism across multiple cancer types.

Specifications

• Antigen: BRIP1
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 28 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
• Gene: BRIP1
• Gene Accession No.: Q9BX63
• Gene Alias: 3110009N10Rik; 8030460J03Rik; ATP-dependent RNA helicase BRIP1; BACH 1; Bach1; BACH1 BRIP1; BRCA1 interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP 1; Brip1; FACJ; FANCJ; FANCJ protein; Fanconi anemia group J protein; Fanconi anemia group J protein homolog; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
• Gene Symbols: BRIP1
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to amino acids near the carboxy terminus of human BACH1.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 83990
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG