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Invitrogen™ BRIP1 Polyclonal Antibody
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Catalog No. PIPA5110693
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100 μL
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PIPA5110693 100 μL
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Catalog No. PIPA5110693 Supplier Invitrogen™ Supplier No. PA5110693
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FNKQTKRVSW SSFNSLGQYF TGKIPKATPE LGSSENSASS PPRFKTEKME SKTVLPFTDK CESSNLTVNT SFGSCPQSET IISSLKIDAT LTRKNHSEHP LCSEEALDPD IELSLVSEED KQSTSNRDFE TEAEDESIYF TPEL Highest antigen sequence indentity to the following orthologs: Mouse - 47%, Rat - 47%.

BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) is a gene situated on chromosome 17q22, covering 19 exons within its 184-kb coding region to encode a protein containing 1249 amino acids. BRIP1 is integral to the DNA repair processes, specifically through its interaction with the BRCA1 gene, and is involved in the Fanconi anemia complementation group J (FANC J). Mutations in BRIP1 have been identified, playing a role in cancer predisposition with a notable eightfold increased risk for ovarian cancer and associations with cervical cancer risk through its single nucleotide polymorphisms (SNPs). Amplifications and other mutations of BRIP1 are prevalent in a variety of cancers, and its expression involves significant correlations with copy number variations (CNV) and DNA methylation across numerous tumor types. BRIP1's expression is upregulated in certain contexts, which can contribute to cancer progression, as evidenced in the Omani population with breast cancer. These interactions validate its association with DNA damage repair, cell cycle, and metabolism across multiple cancer types.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRIP1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.30 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BRIP1
Gene Accession No. Q9BX63
Gene Alias 3110009N10Rik; 8030460J03Rik; ATP-dependent RNA helicase BRIP1; BACH 1; Bach1; BACH1 BRIP1; BRCA1 interacting protein C-terminal helicase 1; BRCA1/BRCA2-associated helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP 1; Brip1; FACJ; FANCJ; FANCJ protein; Fanconi anemia group J protein; Fanconi anemia group J protein homolog; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols BRIP1
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human BRIP1. Recombinant protein control fragment (Product #RP-102519).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 83990
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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