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Invitrogen™ BRSK2 Polyclonal Antibody
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Catalog No. PIPA5103338
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PIPA5103338 100 μL
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Catalog No. PIPA5103338 Supplier Invitrogen™ Supplier No. PA5103338
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total BRSK2.

BRSK2 is a brain-selective serine/threonine kinase 2 that is mainly expressed in the brain, with weaker expression in testis and pancreas. BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C and CDC25B in an in vitro assay. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhanced endogenous BRSK2 kinase activity in a caffeine-sensitive manner and caused translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C. DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus. Overexpression of BRSK2 induces G2/M arrest in HeLa cells. Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest. BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRSK2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Brsk2
Gene Accession No. D3ZML2, Q69Z98, Q8IWQ3
Gene Alias 4833424K13Rik; BR serine/threonine kinase 2; BR serine/threonine-protein kinase 2; brain serine/threonine kinase 2; brain-selective kinase 2; Brain-specific serine/threonine-protein kinase 2; BRSK2; C11orf7; HUSSY-12; Kiaa4256; PEN11B; protein kinase SAD1B; SAD1; SAD1B; Sada; SAD-A; serine/threonine-protein kinase 29; Serine/threonine-protein kinase BRSK2; serine/threonine-protein kinase SAD-A; STK29; testicular tissue protein Li 30
Gene Symbols Brsk2
Host Species Rabbit
Immunogen A synthesized peptide derived from human BRSK2(Accession Q8IWQ3), corresponding to amino acid residues H234-P284.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 293631, 75770, 9024
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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