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Invitrogen™ BRUCE Polyclonal Antibody
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Catalog No. PA550487
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100 μL
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PA550487 100 μL
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Catalog No. PA550487 Supplier Invitrogen™ Supplier No. PA550487
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total BIRC6 protein.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BRUCE
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene BIRC6
Gene Accession No. Q9NR09
Gene Alias A430032G04Rik; A430040A19Rik; AA501170; APOLLON; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; Birc6; BRUCE; D630005A10Rik; KIAA1289; mKIAA1289; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
Gene Symbols BIRC6
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues near the C terminal of human Baculoviral IAP repeat-containing protein 6.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57448
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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