Invitrogen™ BRUCE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA550487

Catalog No. PA550487

Description

The antibody detects endogenous levels of total BIRC6 protein.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Specifications

• Antigen: BRUCE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BIRC6
• Gene Alias: A430032G04Rik; A430040A19Rik; AA501170; APOLLON; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; Birc6; BRUCE; D630005A10Rik; KIAA1289; mKIAA1289; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57448
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q9NR09
• Gene Symbols: BIRC6
• Immunogen: Synthetic peptide corresponding to residues near the C terminal of human Baculoviral IAP repeat-containing protein 6.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG