Invitrogen™ BRUCE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114907

Catalog No. PIPA5114907

Description

Antibody detects endogenous levels of total BIRC6.

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Specifications

• Antigen: BRUCE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BIRC6
• Gene Alias: A430032G04Rik; A430040A19Rik; AA501170; APOLLON; baculoviral IAP repeat containing 6; baculoviral IAP repeat-containing 6; baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6; BIR repeat-containing ubiquitin-conjugating enzyme; Birc6; BRUCE; D630005A10Rik; KIAA1289; mKIAA1289; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; ubiquitin-conjugating BIR-domain enzyme apollon
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12211, 57448
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O88738, Q9NR09
• Gene Symbols: BIRC6
• Immunogen: A synthesized peptide derived from human BIRC6(Accession Q9NR09), corresponding to amino acid residues L4692-E4742.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov