Invitrogen™ BTBD12 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA564270

Catalog No. PIPA564270

Description

Immunogen sequence: LIQYVNNEGF SAVEDGVLTQ RVLLGDVSTE AARTFLHYLY TADTGLPPGL SSELSSLAHR FGVSELVHLC EQVPIATDSE GKPWEEKEAE NCESRA Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 69%.

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.

Specifications

• Antigen: BTBD12
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SLX4
• Gene Alias: BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; BTBD12; FANCP; KIAA1784; KIAA1987; MUS312; SLX4; SLX4 structure-specific endonuclease subunit; SLX4 structure-specific endonuclease subunit homolog; structure-specific endonuclease subunit SLX4
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84464
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IY92
• Gene Symbols: SLX4
• Immunogen: Recombinant protein corresponding to Human BTBD12.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG