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Invitrogen™ BTLA Chimeric Recombinant Rabbit Monoclonal Antibody (HMBT-6B2)
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Catalog No. PIMA548131
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200 μg
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Catalog No. Quantity
PIMA548131 200 μg
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Catalog No. PIMA548131 Supplier Invitrogen™ Supplier No. MA548131
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: This antibody is specific for B and T lymphocyte attenuator (BTLA), which functions as a negative regulator of T cell activation and proliferation, and attenuates B cell proliferation upon associating with its known ligand, herpes virus entry mediator (HVEM).

BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BTLA Chimeric
Applications ELISA, Flow Cytometry, Functional Assay, Inhibition Assays, Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone HMBT-6B2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene BTLA
Gene Accession No. Q7TSA3
Gene Alias A630002H24; B and T lymphocyte associated; B and T lymphocyte associated protein; B and T lymphocyte attenuator; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA; BTLA_HUMAN; BTLA1; CD272; CD272 antigen; FLJ16065; MGC129743
Gene Symbols BTLA
Host Species Rabbit
Immunogen This antibody was raised by immunising Armenian hamsters with mouse BTLA:Fc fusion protein.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 208154
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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