Invitrogen™ BTRC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144646

Catalog No. FEPA5144646

Description

Positive control: HepG2 cell lysate, Hela cell lysate, 293T cell lysate, mouse testis tissue lysate, rat brain tissue lysate, mouse brain tissue lysate, A549, human colon tissue, mouse large intestine tissue. Predicted band size: 69 kDa Subcellular Location: Cytoplasm, Nucleus.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Specifications

• Antigen: BTRC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BTRC
• Gene Alias: beta-transducin repeat containing E3 ubiquitin protein ligase; beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; betaTrCP; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; Btrc; BTRCP; b-TrCP; bTrCP1; E3RSIkappaB; E3RS-IkappaB; epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A; mE3RS-IkappaB; pIkappaBalpha-E3 receptor subunit; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; Ubiquitin ligase FWD1
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12234, 361765, 8945
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q3ULA2, Q9Y297
• Gene Symbols: BTRC
• Immunogen: Recombinant protein within Human Beta TRCP aa 1-200/605.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG