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Invitrogen™ BTRC Polyclonal Antibody
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Catalog No. PIPA5111014
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100 μL
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PIPA5111014 100 μL
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Catalog No. PIPA5111014 Supplier Invitrogen™ Supplier No. PA5111014
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ALKFMNSSER EDCNNGEPPR KIIPEKNSLR QTYNSCARLC LNQETVCLAS TAMKTENCVA KTKLANGTSS MIVPKQRKLS ASYEKEKELC VKYFEQWSES DQVEFVEHLI SQMCHYQHGH Highest antigen sequence indentity to the following orthologs: Rat - 95%, Mouse - 98%.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BTRC
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.50 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene BTRC
Gene Accession No. Q9Y297
Gene Alias beta-transducin repeat containing E3 ubiquitin protein ligase; beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; betaTrCP; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; Btrc; BTRCP; b-TrCP; bTrCP1; E3RSIkappaB; E3RS-IkappaB; epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A; mE3RS-IkappaB; pIkappaBalpha-E3 receptor subunit; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; Ubiquitin ligase FWD1
Gene Symbols BTRC
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human BTRC. Recombinant protein control fragment (Product #RP-104626).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8945
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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