Invitrogen™ BTRC Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142087

Catalog No. PIPA5142087

Description

Additional Information: This antibody is expected to recognise both reported isoforms (NP_378663.1; NP_003930.1). This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:128,000.

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.

Specifications

• Antigen: BTRC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BTRC
• Gene Alias: beta-transducin repeat containing E3 ubiquitin protein ligase; beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; betaTrCP; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; Beta-Trcp1; Btrc; BTRCP; b-TrCP; bTrCP1; E3RSIkappaB; E3RS-IkappaB; epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; LOW QUALITY PROTEIN: F-box/WD repeat-containing protein 1A; mE3RS-IkappaB; pIkappaBalpha-E3 receptor subunit; pIkappaB-E3 receptor subunit; SCF b-TRCP; Slimb; Ubiquitin ligase FWD1
• Host Species: Goat
• Purification Method: Ammonium sulfate precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 8945
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9Y297
• Gene Symbols: BTRC
• Immunogen: Peptide with sequence DPAEAVLQEKALK-C (aa 2-14).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG