Invitrogen™ Burosumab Recombinant Human Monoclonal Antibody

Catalog No.	Quantity
PIMA542118	100 μg

Catalog No. PIMA542118 Supplier Invitrogen™ Supplier No. MA542118

Description

Human Recombinant Monoclonal Antibody

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Burosumab is a biosimilar that targets FGF23. The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.

Specifications

• Antigen: Burosumab
• Applications: ELISA, SDS-Page
• Classification: Recombinant Monoclonal
• Concentration: 1.42 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.5
• Gene Alias: KRN-23; UX-023
• Host Species: Human
• Immunogen: Human FGF23.
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ
• Target Molecule: Chemical

Safety and Handling

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