BV480 CD103 Rat anti-Mouse, Brilliant Violet 480, Clone: M290, BD
Rat Monoclonal Antibody
Manufacturer: BD Biosciences 566201
The M290 antibody specificaly binds to CD103, the chain of IEL 7 integrin. CD103 has a unique and fairly restricted tissue distribution. It is expressed on almost all intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells (DEC), subpopulations of peripheral T cells, and distinct subsets of fetal, neonatal, and adult thymocytes. E-cadherin is the epithelial cell ligand for α IEL β 7 integrin. The ordered expression of α IEL during thymocyte development (which occurs under the influence of the thymic epithelium), high level of α IEL expression on peripheral T cells in epithelial tissues (IEL and DEC), and expression of CD103 on a subset of CD8+ lymphocytes responding to allogeneic epithelial cells, suggest that α IEL β 7 integrin may have a common role in the interactions of T lymphocytes with epithelia during T-cell maturation and effector functions. CD103 is thought to play a role in allograft rejection. The M290 antibody is reported to efficiently inhibit α IEL β 7-mediated adhesion in in vitro /assays.The antibody was conjugated to BD Horizon BV480 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 436nm and Em Max at 478nm, BD Horizon BV480 can be excited by the violet laser and detected in the BD Horizon BV510 (525/40nm) filter set. BV480 has less spillover into the BV605 detector and, in general, is brighter than BV510.
BD Horizon™ BV480 is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 436nm and Em Max at 478nm, BD Horizon BV480 can be excited by the violet laser and detected in the BD Horizon™ BV510 (525/40nm) filter set. BV480 has less spillover into the BD Horizon™ BV605 detector and, in general, is brighter than BD Horizon BV510. Due to similar excitation and emission properties, BV480, BV510 and V500 cannot be used simultaneously.
|Aqueous buffered solution containing BSA and ≤0.09% sodium azide.|
|Itgae, Integrin alpha-E, αE, alpha-E1, ITAE, Integrin αIEL chain, aM290|
|Mouse Intestinal Epithelial Cells|
|The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. The antibody was conjugated with BD Horizon BV480 under optimum conditions, and unconjugated antibody and free BD Horizon BV480 were removed.|
|Brilliant Violet 480|
|Rat LOU, also known as Louvain, LOU/C, LOU/M IgG2a, κ|
|Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.|
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