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  5. Tocris Bioscience™ C 101248

Tocris Bioscience™ C 101248
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Catalog No. 800750
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Selective and potent inhibitor of both mouse and human THIK-1

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

Specifications

Chemical Name or Material 4-[1-(4-Pyridinylmethyl)-1 H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
CAS 361368-24-3
Quantity 50 mg
Target Two-P Potassium Channels Blockers
Molecular Formula C15H12N6O
Purity 0.98
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