Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ C 101248

Tocris Bioscience™ C 101248
GREENER_CHOICESDP

Catalog No. 800750 Shop All Novus Biologicals Products
Change view
Click to view available options
Quantity:
10 mg
50 mg
2 product options available for selection
Product selection table with 2 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
80-075-0 50 mg
80-071-0 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 2 options available.
2 options
This item is not returnable. View return policy
Catalog No. 80-075-0 Supplier Tocris Bioscience™ Supplier No. 8007/50
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Selective and potent inhibitor of both mouse and human THIK-1

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50 = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and Kv2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K+ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

Specifications

Chemical Name or Material 4-[1-(4-Pyridinylmethyl)-1 H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
CAS 361368-24-3
Quantity 50 mg
Target Two-P Potassium Channels Blockers
Molecular Formula C15H12N6O
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.