Invitrogen™ c-Cbl Monoclonal Antibody (3B12)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA515885

Catalog No. PIMA515885

Description

MA5-15885 targets C-CBL in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-15885 immunogen is purified recombinant fragment of human C-CBL expressed in E. Coli. MA5-15885 detects C-CBL which has a predicted molecular weight of approximately 120kDa.

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Specifications

• Antigen: c-Cbl
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.03% sodium azide
• Gene Accession No.: P22681, P22682
• Gene Symbols: Cbl
• Immunogen: Purified recombinant fragment of human C-CBL expressed in E. Coli.
• Regulatory Status: RUO
• Gene ID (Entrez): 12402, 500985, 867
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 3B12
• Conjugate: Unconjugated
• Gene: Cbl
• Gene Alias: 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1