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Invitrogen™ c-Cbl Monoclonal Antibody (3B12)
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA515885
Description
MA5-15885 targets C-CBL in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-15885 immunogen is purified recombinant fragment of human C-CBL expressed in E. Coli. MA5-15885 detects C-CBL which has a predicted molecular weight of approximately 120kDa.
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Specifications
c-Cbl | |
Monoclonal | |
Conc. Not Determined | |
Ascites with 0.03% sodium azide | |
P22681, P22682 | |
Cbl | |
Purified recombinant fragment of human C-CBL expressed in E. Coli. | |
RUO | |
12402, 500985, 867 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
3B12 | |
Unconjugated | |
Cbl | |
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL | |
Mouse | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG1 |
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