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Invitrogen™ c-Cbl Monoclonal Antibody (3B12)
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Catalog No. PIMA515885
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PIMA515885 100 μL
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Catalog No. PIMA515885 Supplier Invitrogen™ Supplier No. MA515885
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Description

Mouse Monoclonal Antibody

MA5-15885 targets C-CBL in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with Human, mouse, and Rat samples. The MA5-15885 immunogen is purified recombinant fragment of human C-CBL expressed in E. Coli. MA5-15885 detects C-CBL which has a predicted molecular weight of approximately 120kDa.

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
TRUSTED_SUSTAINABILITY

Specifications

Antigen c-Cbl
Applications ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 3B12
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Ascites with 0.03% sodium azide
Gene Cbl
Gene Accession No. P22681, P22682
Gene Alias 4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Gene Symbols Cbl
Host Species Mouse
Immunogen Purified recombinant fragment of human C-CBL expressed in E. Coli.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12402, 500985, 867
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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