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Invitrogen™ c-Cbl Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520299

Catalog No. PIPA520299


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Description

Description

A suggested positive control is Daudi cell lysate. PA5-20299 can be used with blocking peptide PEP-0423.

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

c-Cbl
Polyclonal
Unconjugated
Cbl
4732447J05Rik; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Casitas B-lineage lymphoma; casitas B-lineage lymphoma proto-oncogene; CBL; Cbl proto-oncogene; Cbl proto-oncogene, E3 ubiquitin protein ligase; CBL2; Cbl-2; CBL-3; CBLC; c-Cbl; E3 ubiquitin-protein ligase CBL; FRA11B; fragile site, folic acid type, rare, fra(11)(q23.3); NSLL; oncogene CBL2; proto-oncogene c-Cbl; RGD1561386; RING finger protein 55; RING-type E3 ubiquitin transferase CBL; RNF55; RNF57; signal transduction protein CBL
Rabbit
Antigen affinity chromatography
RUO
12402, 500985, 867
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
P22681, P22682
Cbl
A 14 amino acid peptide from near the carboxy terminus of human cbl.
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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