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c-Cbl Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A302338A

Description
The recommended shelf life for this product is 1 year from date of receipt.
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.Specifications
c-Cbl | |
Polyclonal | |
Unconjugated | |
CBL | |
CBL; CBL2; C-CBL; RNF55; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Cas-Br-M ecotropic retroviral transforming sequence (Oncogene C | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
867 | |
4° C | |
Liquid |
Immunoprecipitation, Western Blot | |
0.2 mg/ml | |
TBS with 0.1% BSA and 0.09% sodium azide | |
P22681 | |
CBL | |
Between 675 and 725 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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