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c-Cbl Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A302338A

Encompass_Preferred

Catalog No. 50-156-2351


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt.

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
Specifications

Specifications

c-Cbl
Polyclonal
Unconjugated
CBL
CBL; CBL2; C-CBL; RNF55; Cas-Br-M (murine) ecotropic retroviral transforming sequence; Cas-Br-M ecotropic retroviral transforming sequence (Oncogene C
Rabbit
Antigen affinity chromatography
RUO
867
4° C
Liquid
Immunoprecipitation, Western Blot
0.2 mg/ml
TBS with 0.1% BSA and 0.09% sodium azide
P22681
CBL
Between 675 and 725
100 μL
Primary
Human
Antibody
IgG
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