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c-Myc Mouse anti-Human, Biotin, Clone: MYC275 + MYC909, Novus Biologicals™
Mouse Monoclonal Antibody
Supplier: Novus Biologicals NBP247739B
SDSDocumentsProduct Certifications Promotions
Descriptionc-Myc Monoclonal specifically detects c-Myc in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.
|PBS with 0.05% Sodium Azide|
|Recombinant human c-Myc protein (Uniprot: P01106)|
|Protein A or G purified|
|Autophagy, Cancer, Cancer Stem Cells, Cell Cycle and Replication, Chromatin Research, Core ESC Like Genes, Epigenetics, Epitope Tags, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors|
|Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence|
|MYC275 + MYC909|
|Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence|
|avian myelocytomatosis viral oncogene homolog, BHLHE39, bHLHe39MRTL, Class E basic helix-loop-helix protein 39, c-Myc, MYC, myc proto-oncogene protein, MYCC, myc-related translation/localization regulatory factor, Proto-oncogene c-Myc, Transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian)|
|It recognizes a transcription factor of 64-67kDa, identified as c-myc. This monoclonal antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over-expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease. Rearrangement of the MYC gene is found in 3% to 16% of diffuse large B-cell lymphoma (DLBCLs) and in nearly 100% of Burkitt lymphomas (BL). Identifying MYC status is important in establishing final diagnosis of DLBCL, BL, or B-cell lymphoma, with features intermediate between DLBCL and BL as well as in differential diagnoses of the lymphomas.|
|Store at 4C in the dark.|
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