c-Myc Mouse anti-Human, Biotin, Clone: MYC275 + MYC909, Novus Biologicals™

Mouse Monoclonal Antibody

Supplier:  Novus Biologicals NBP247739B

Catalog No. NBP47739B

Description

c-Myc Monoclonal specifically detects c-Myc in Human samples. It is validated for Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunofluorescence.

Specifications

• Antigen: c-Myc
• Classification: Monoclonal
• Conjugate: Biotin
• Formulation: PBS with 0.05% Sodium Azide
• Gene Symbols: MYC
• Immunogen: Recombinant human c-Myc protein (Uniprot: P01106)
• Purification Method: Protein A or G purified
• Research Discipline: Autophagy, Cancer, Cancer Stem Cells, Cell Cycle and Replication, Chromatin Research, Core ESC Like Genes, Epigenetics, Epitope Tags, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
• Gene ID (Entrez): 4609
• Target Species: Human
• Form: Purified

• Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence
• Clone: MYC275 + MYC909
• Dilution: Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunofluorescence
• Gene Alias: avian myelocytomatosis viral oncogene homolog, BHLHE39, bHLHe39MRTL, Class E basic helix-loop-helix protein 39, c-Myc, MYC, myc proto-oncogene protein, MYCC, myc-related translation/localization regulatory factor, Proto-oncogene c-Myc, Transcription factor p64, v-myc avian myelocytomatosis viral oncogene homolog, v-myc myelocytomatosis viral oncogene homolog (avian)
• Host Species: Mouse
• Molecular Weight of Antigen: 63 kDa
• Quantity: 0.1 mL
• Primary or Secondary: Primary
• Test Specificity: It recognizes a transcription factor of 64-67kDa, identified as c-myc. This monoclonal antibody shows no cross-reaction with v-myc. c-myc is involved in the control of cell proliferation and differentiation and is amplified and/or over-expressed in a variety of tumors. Over-expression of c-myc protein occurs frequently in luminal cells of prostate intraepithelial neoplasia as well as in most primary carcinomas and metastatic disease. Rearrangement of the MYC gene is found in 3% to 16% of diffuse large B-cell lymphoma (DLBCLs) and in nearly 100% of Burkitt lymphomas (BL). Identifying MYC status is important in establishing final diagnosis of DLBCL, BL, or B-cell lymphoma, with features intermediate between DLBCL and BL as well as in differential diagnoses of the lymphomas.
• Content And Storage: Store at 4C in the dark.
• Isotype: IgG1 κ