c-Myc Mouse anti-Human, Magnetic beads, Polyclonal, liquid, TrueMAB™

Catalog No.	Quantity
50-786-588	1 mL

Catalog No. 50-786-588 Supplier OriGene Supplier No. TA150044

Description

Mouse Polyclonal Antibody

Synthetic peptide EQKLISEEDL conjugated to KLH

The c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.

Specifications

• Antigen: c-Myc
• Applications: Immunoprecipitation
• Classification: Polyclonal
• Clone: 9E10
• Concentration: 5 mg/mL
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: MYC
• Gene Accession No.: P01106
• Gene Alias: anti-Myc, tag antibody, Anti-myc Antibody, anti-myc antibodies, myc antibody, cmyc antibody, c-myc antibody, anti myc, anti cmyc, anti c-myc, 9E10 myc, 9E10 anti myc, 9E10 antibody, mag bead, magnetic
• Gene Symbols: MYC
• Host Species: Mouse
• Immunogen: Synthetic peptide conjugated to KLH, corresponding to C terminal amino acids 408-432 of human c-Myc
• Purification Method: Protein G
• Quantity: 1 mL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 4609
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1