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MilliporeSigma™ C-Reactive Protein, Mouse, Unlabeled, Clone: 2A8.1,

Catalog No. MABF1070MI Shop All MilliporeSigma Products
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Quantity:
100 μg
Conjugate:
Unconjugated
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Catalog No. Quantity Conjugate
MABF1070MI 100 μg Unconjugated
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Catalog No. MABF1070MI Supplier MilliporeSigma™ Supplier No. MABF1070

Description

Mouse Monoclonal Antibody

C-reactive protein (UniProt P02741) is encoded by the CRP (also known as PTX1) gene (Gene ID 1401) in human. CRP is the classical acute phase reactant produced by the liver and its circulating concentration increases rapidly in a cytokine-mediated response to tissue injury, infection, and inflammation. It is an annular, pentameric protein that binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and bacteria in order to activate the complement system via the C1Q complex. Interleukin-6 (IL-6), produced by macrophages in response to injury and infection, is a major trigger for the synthesis of CRP by the liver. It plays a major role in early host defense by promoting agglutination, bacterial capsular swelling, phagocytosis, and complement fixation through its calcium-dependent binding to phosphorylcholine. It can also interact with DNA and histones and scavenge nuclear material released from damaged circulating cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C-Reactive Protein
Applications Western Blot
Classification Monoclonal
Clone 2A8.1
Concentration Please refer to lot specific datasheet.
Conjugate Unconjugated
Formulation Purified mouse IgG2bκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene CRP, PTX1
Gene Accession No. P02741
Host Species Mouse
Immunogen GST-tagged recombinant human C-reactive protein C-terminal fragment.
Purification Method Protein G Purified
Quantity 100 μg
Regulatory Status RUO
Research Discipline Inflammation & Immunology
Primary or Secondary Primary
Gene ID (Entrez) NP_000558
Test Specificity Clone 2A8.1 targets an epitope within the C-terminal half of human C-reactive protein.
Target Species Human
Content And Storage Stable for 1 year at 2°-8°C from date of receipt.
Form Purified
Isotype IgG2b κ
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For Research Use Only. Not for use in diagnostic procedures.

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