Invitrogen™ C10orf99 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562266

Catalog No. PIPA562266

Description

Immunogen sequence: KRRPAKAWSG RRTRLCCHRV PSPNSTNLKG HHVRLCKPCK LEPEPRLWVV PGALPQV Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 46%.

GPR15L is a newly identified ligand for GPR15, a member of the G protein-coupled receptor (GPCR) family. Upon ligation, GPR15L acts as a potent chemoattractant for GPR15-expressing T cells and together they mediate lymphocyte recruitment to the large intestine and skin. GPR15L is constitutively expressed by colon epithelial cells where its expression is minimally altered by intestinal inflammation. Conversely, GPR15L is nearly undetectable in adult epidermis but highly upregulated during wound healing and inflammation, particularly in psoriasis. Significant expression of GPR15L is also seen in additional mucosal epithelial cells, including those of the stomach, esophagus, and urinary tract. While maintaining similar expression patterns and intramolecular disulfide cysteine bridges found in members of the CC chemokine family, GPR15L differs from classic CC and CXC chemokines, whose active sites are found on the N-terminus, in that it relies on its C-terminus for receptor interaction. GPR15L was first identified as an antimicrobial peptide (AMP) due to its broad spectrum of antimicrobial activity, a property shared with many chemokines. GPR15L binds to an additional receptor, SUSD2, and early studies have indicated that both are downregulated in colon cancer tissue resulting in inhibited colon cancer growth.

Specifications

• Antigen: C10orf99
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C10orf99
• Gene Alias: Antimicrobial peptide with 57 amino acid residues; anti-microbial peptide with 57 amino acid residues; antimicrobial peptide-57; AP-57; C10orf99; chromosome 10 open reading frame 99; colon-derived SUSD2 binding factor; CSBF; GPR15L; Protein GPR15L; RLLV1833; secreted protein C10orf99; UNQ1833; UNQ1833/PRO3446
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 387695
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.20 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6UWK7
• Gene Symbols: C10orf99
• Immunogen: Recombinant protein corresponding to Human C10orf99. Recombinant protein control fragment (Product #RP-90605).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG