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Invitrogen™ C11orf54 Polyclonal Antibody
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Catalog No. PIPA542029
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100 μL
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Catalog No. Quantity
PIPA542029 100 μL
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Catalog No. PIPA542029 Supplier Invitrogen™ Supplier No. PA542029
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Description

Rabbit Polyclonal Antibody

Peptide sequence: CPDLTKEPFT FPVKGICGKT RIAEVGGVPY LLPLVNQKKV YDLNKIAKEI Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%; Zebrafish: 79%.

C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C11orf54
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene C11orf54
Gene Accession No. Q9H0W9
Gene Alias C11orf54; chromosome 11 open reading frame 54; ester hydrolase C11orf54; Ester hydrolase C11orf54 homolog; LP4947; PTD012; PTOD012; RGD1309534; similar to RIKEN cDNA 4931406C07
Gene Symbols C11orf54
Host Species Rabbit
Immunogen Synthetic peptide directed towards the N-terminal of human C11orf54 (aa 38-87).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28970
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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