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Invitrogen™ C11orf54 Polyclonal Antibody
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Catalog No. PIPA559062
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100 μL
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Catalog No. Quantity
PIPA559062 100 μL
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Catalog No. PIPA559062 Supplier Invitrogen™ Supplier No. PA559062
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 93%.

C11orf54, also known as Chromosome 11 Open Reading Frame 54, is an ester hydrolase highly conserved across various species. Located on chromosome 11, the gene is identified as a biomarker associated with renal cancers, although its precise biological function is not fully elucidated. Research has shown that C11orf54 plays a role in DNA repair mechanisms, particularly by blocking chaperone-mediated autophagy (CMA). Silencing this gene reduces cellular proliferation and heightens DNA damage and apoptosis when cells are treated with cisplatin, a common chemotherapeutic agent. This suggests C11orf54's involvement in cancer pathology, particularly its potential impact on DNA repair pathways, thereby supporting cell survival post DNA damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C11orf54
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene C11orf54
Gene Accession No. Q5U2Q3, Q9H0W9
Gene Alias C11orf54; chromosome 11 open reading frame 54; ester hydrolase C11orf54; Ester hydrolase C11orf54 homolog; LP4947; PTD012; PTOD012; RGD1309534; similar to RIKEN cDNA 4931406C07
Gene Symbols C11orf54, RGD1309534
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human C11orf54. Recombinant protein control fragment (Product #RP-97517).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28970, 363016
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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