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Invitrogen™ C12orf41 Polyclonal Antibody
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Catalog No. PIPA531577
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100 μL
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PIPA531577 100 μL
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Catalog No. PIPA531577 Supplier Invitrogen™ Supplier No. PA531577
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, Jurkat, Raji. Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (81%), Xenopus laevis (83%), Pig (100%), Bovine (99%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The C12orf41 gene, also known as CFAP70 (Cilia and Flagella Associated Protein 70), is located on chromosome 12 and encodes a protein that is essential for the proper function of cilia and flagella. The CFAP70 protein plays a critical role in the assembly and maintenance of axonemal structures, which are core components of cilia and flagella. Cilia and flagella are vital for various cellular processes, including motility, fluid movement across cell surfaces, and signal transduction. Mutations in CFAP70 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory tract infections, abnormal situs (organ positioning), and infertility due to defective motility of cilia and flagella. CFAP70 is also involved in the regulation of dynein arms and radial spokes, which are necessary for the effective beating of cilia and flagella. Research into CFAP70 continues to uncover its multifaceted roles in cellular function and its potential implications in ciliopathies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C12orf41
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene KANSL2
Gene Accession No. Q9H9L4
Gene Alias 2310037I24Rik; B930009D17; C12orf41; Kansl2; KAT8 regulatory NSL complex subunit 2; non-specific lethal 2 homolog; NSL complex protein NSL2; NSL2
Gene Symbols KANSL2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human C12orf41. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54934
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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