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Invitrogen™ C12orf66 Polyclonal Antibody
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Catalog No. PIPA565744
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100 μL
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Catalog No. Quantity
PIPA565744 100 μL
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Catalog No. PIPA565744 Supplier Invitrogen™ Supplier No. PA565744
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EKVYHSLTYL GQKLGGQSFF SRKDSIRTIY TSLHNELKKV VTGRGALGGT APHVEELLSH LSEQLCFFVQ ARMEMADFYE KMYTLSTQKF INA.

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C12orf66
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene C12orf66
Gene Accession No. Q96MD2
Gene Alias C12orf66; chromosome 12 open reading frame 66; KICSTOR complex protein C12orf66; UPF0536 protein; UPF0536 protein C12orf66
Gene Symbols C12orf66
Host Species Rabbit
Immunogen Recombinant Human C12orf66. Recombinant protein control fragment (Product #RP-106420).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 144577
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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