Invitrogen™ C12orf66 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA565744

Catalog No. PIPA565744

Description

Immunogen sequence: EKVYHSLTYL GQKLGGQSFF SRKDSIRTIY TSLHNELKKV VTGRGALGGT APHVEELLSH LSEQLCFFVQ ARMEMADFYE KMYTLSTQKF INA.

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Specifications

• Antigen: C12orf66
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C12orf66
• Gene Alias: C12orf66; chromosome 12 open reading frame 66; KICSTOR complex protein C12orf66; UPF0536 protein; UPF0536 protein C12orf66
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 144577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96MD2
• Gene Symbols: C12orf66
• Immunogen: Recombinant Human C12orf66. Recombinant protein control fragment (Product #RP-106420).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov