Invitrogen™ C14orf129 Monoclonal Antibody (2F2)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524550

Catalog No. PIMA524550

Description

Peptide Sequence: METDCNPMEL SSMSGFEEGS ELNGFEGTDM KDMRLEAEAV VNDVLFAVNN MFVSKSLRCA DDVAYINVET KERNRYCLEL TEAGLKVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE AFGNALLQRL EALKRDGQS.

This gene encodes a protein that is involved as a negative regulator of GSK3-beta in the Wnt signaling pathway. The encoded protein may play a role in the retinoic acid signaling pathway by regulating the functional interactions between GSK3-beta, beta-catenin and cyclin D1, and it regulates the beta-catenin/N-cadherin pool. The encoded protein contains a GSK3-beta interacting domain (GID) in its C-terminus, which is similar to the GID of Axin. The protein also contains an evolutionarily conserved RII-binding domain, which facilitates binding with protein kinase-A and GSK3-beta, enabling its role as an A-kinase anchoring protein. Alternatively spliced transcript variants have been observed for this gene.

Specifications

• Antigen: C14orf129
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: Q9P0R6
• Gene Symbols: GSKIP
• Immunogen: C14orf129 (NP_057556.2, 1 a.a. ~ 139 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: ELISA, Western Blot, Immunocytochemistry
• Clone: 2F2
• Conjugate: Unconjugated
• Gene: GSKIP
• Gene Alias: 4933433P14Rik; C14orf129; GSK3B interacting protein; GSK3beta interaction protein; GSK3-beta interaction protein; GSK3B-interacting protein; GSKIP; HSPC210; MGC4945; RGD1308470
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 51527
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid