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Invitrogen™ C14orf21 Polyclonal Antibody
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Catalog No. PIPA531719
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100 μL
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PIPA531719 100 μL
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Catalog No. PIPA531719 Supplier Invitrogen™ Supplier No. PA531719
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: A549. Predicted reactivity: Mouse (80%), Rat (83%), Rhesus Monkey (98%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The C14orf21 gene, also known as SLIRP (SRA stem-loop interacting RNA binding protein), is located on chromosome 14 and encodes a mitochondrial protein involved in RNA processing. SLIRP is crucial for the stabilization and regulation of mitochondrial-encoded RNAs, which play a vital role in mitochondrial gene expression and overall mitochondrial function. The SLIRP protein interacts with RNA stem-loop structures, particularly those involved in the steroid receptor RNA activator (SRA), thereby regulating gene expression by modulating the activity of nuclear receptors. Defects in SLIRP can lead to impaired mitochondrial function, resulting in various clinical manifestations, including mitochondrial myopathy and other disorders related to mitochondrial dysfunction.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C14orf21
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene NOP9
Gene Accession No. Q86U38
Gene Alias C14orf21; KIAA2021; NOP9; NOP9 nucleolar protein; NOP9 nucleolar protein homolog; nucleolar protein 9; pumilio domain-containing protein C14orf21
Gene Symbols NOP9
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human C14orf21. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 161424
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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