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R&D Systems™ C16
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Catalog No. 538250 Shop All Novus Products
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Catalog No. 538250 Supplier R&D Systems™ Supplier No. 5382/50

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Description

A Tocris product, part of R&D Systems. PKR inhibitor

C16 is a PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

Specifications

Chemical Name or Material C16
CAS 608512-97-6
Synonym 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one
Quantity 50 mg
Solubility Soluble to 50mM in DMSO and to 20mM in ethanol
Product Line Tocris
Molecular Formula C13H8N4OS
Formula Weight 268.29
Physical Form Solid
Product Type Bioactive Small Molecule
Purity >98%
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Research Use Only. Not For Human or Veterinary Use

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