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Invitrogen™ C16orf62 Polyclonal Antibody
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Catalog No. PIPA565802
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100 μL
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PIPA565802 100 μL
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Catalog No. PIPA565802 Supplier Invitrogen™ Supplier No. PA565802
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FDFLLTFKQIH GDTVQNQLVV QGVELPSYLP LYPPAMDWIF QCISYHAPEA LLTEMMERCK KLGNNALLLN SVMSAFRAEF IATRSMDFIG M Highest antigen sequence identity to the following orthologs - mouse 93%, rat 95%.

Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079). Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association with the CCC complex and cooperation with the WASH complex on early endosomes. Seems not to be required for CCC complex stability (PubMed:25355947). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen C16orf62
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene C16orf62
Gene Accession No. Q7Z3J2
Gene Alias 101F10.2; C16orf62; chromosome 16 open reading frame 62; esophageal cancer associated protein; esophageal cancer-associated protein; UPF0505 protein C16orf62; VPS35 endosomal protein sorting factor-like; VPS35L
Gene Symbols C16orf62
Host Species Rabbit
Immunogen Recombinant Human C16orf62. Recombinant protein control fragment (Product #RP-106474).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57020
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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