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Invitrogen™ C17orf53 Monoclonal Antibody (7A3A9)
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Catalog No. PIMA517037
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100 μg
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Catalog No. Quantity
PIMA517037 100 μg
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Catalog No. PIMA517037 Supplier Invitrogen™ Supplier No. MA517037
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Description

Mouse Monoclonal Antibody

MA5-17037 targets C17ORF53 in indirect ELISA, FACS, ICC, IF, and WB applications and shows reactivity with Human samples. The MA5-17037 immunogen is purified recombinant fragment of human C17ORF53 (amino acids: 282-527) expressed in E. Coli. MA5-17037 detects C17ORF53 which has a predicted molecular weight of approximately 69.8kDa.

C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C17orf53
Applications ELISA, Flow Cytometry, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 7A3A9
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene C17orf53
Gene Accession No. Q8N3J3
Gene Alias C17orf53; chromosome 17 open reading frame 53; uncharacterized protein C17orf53
Gene Symbols C17orf53
Host Species Mouse
Immunogen Purified recombinant fragment of human C17ORF53 (amino acids: 282-527) expressed in E. Coli.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 78995
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b
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