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Invitrogen™ C17orf53 Polyclonal Antibody
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Catalog No. PIPA554662
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100 μL
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PIPA554662 100 μL
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Catalog No. PIPA554662 Supplier Invitrogen™ Supplier No. PA554662
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EQDEFDKVLA SMELEEPGME LECGVSSEAI PILPAQQREG SVLAKKARVV DLSGSCQKGP VPAIHKAGIM SAQDESLDPV IQCRTPRPPL RPGAVGHLPV PTALTVPTQQ LHWEVCPQRS PVQALQP Highest antigen sequence identity to the following orthologs: Mouse - 41%, Rat - 44%.

C17orf53 (chromosome 17 open reading frame 53) is a 647 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
TRUSTED_SUSTAINABILITY

Specifications

Antigen C17orf53
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene C17orf53
Gene Accession No. Q8N3J3
Gene Alias C17orf53; chromosome 17 open reading frame 53; uncharacterized protein C17orf53
Gene Symbols C17orf53
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human C17orf53. Recombinant protein control fragment (Product #RP-93243).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 78995
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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