Invitrogen™ C17orf71 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555202

Catalog No. PIPA555202

Description

Immunogen sequence: SINCLFTVPA NQAFVYIVPG SQEEDPVGML LDQLRSHCTV KDPESLLVPA PLSGPRRYQV MRQHSRQQLS FHIDSSSSSS SGQLVDFTLR EFLWQHVELV LSKKGFDDSV GRNPQPSHFE LPTYQKWISA ASK Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. [UniProt].

Specifications

• Antigen: C17orf71
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SMG8
• Gene Alias: 1200011M11Rik; ABC2; Amplified in breast cancer gene 2 protein; C17orf71; C19H17orf71; CG6729 gene product; FLJ10587; FLJ23205; Protein SMG8; protein smg-8 homolog; RGD1306862; Smg8; smg-8 homolog, nonsense mediated mRNA decay factor; smg-8 homolog, nonsense mediated mRNA decay factor (C. elegans); SMG8 nonsense mediated mRNA decay factor; SMG8, nonsense mediated mRNA decay factor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55181
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8ND04
• Gene Symbols: SMG8
• Immunogen: Recombinant protein corresponding to Human C17orf71. Recombinant protein control fragment (Product #RP-93372).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov