Invitrogen™ C17orf85 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553033

Catalog No. PIPA553033

Description

Immunogen sequence: EYPPAHIEWL DDTSCNVVWL DEMTATRALI NMSSLPAQDK IRSRDASEDK SAEKRKKDKQ EDSSDDDEAE EGEVEDENSS DVELDTLSQV EEESLLRNDL RPANKLAKGN Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Associates with NCBP1/CBP80 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress situations such as virus infections and the NCBP3 activity is critical to inhibit virus growth.

Specifications

• Antigen: C17orf85
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NCBP3
• Gene Alias: 1200014J11Rik; C11H17orf85; C130061O14Rik; C17orf85; C19H17orf85; C78393; C9H17orf85; CTD-3195I5.1; CTD-3195I5.5; ELG; ELG protein; HSA277841; Ncbp3; nuclear cap binding subunit 3; nuclear cap-binding protein subunit 3; Protein ELG; RGD1308139; RIKEN cDNA 1200014J11 gene; similar to RIKEN cDNA 1200014J11; uncharacterized protein C17orf85 homolog
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55421
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q53F19
• Gene Symbols: NCBP3
• Immunogen: Recombinant protein corresponding to Human C17orf85. Recombinant protein control fragment (Product #RP-89980).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov