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C18orf1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501989230
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50-198-9230 100 μL
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Catalog No. 50-198-9230 Supplier Bioss Supplier No. BS9652R
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Description

Rabbit Polyclonal Antibody

Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.

Specifications

Antigen C18orf1
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene LDLRAD4
Gene Accession No. O15165
Gene Alias 8230401C20Rik; A430083H02; A430108L08Rik; C18orf1; clone 22; D18Ertd653e; D330030L18Rik; Ldlrad4; LOC100351001; low density lipoprotein receptor class A domain containing 4; Low-density lipoprotein receptor class A domain-containing protein 4; uncharacterized LOC100351001
Gene Symbols LDLRAD4
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human C18orf1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 753
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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