Invitrogen™ C19orf66 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA559815

Catalog No. PIPA559815

Description

Immunogen sequence: KFHGKASSKK AGALMRKFGS DHTGVGRSIV YGVKQKDGQE LSNDLDAQDP PEDMKQDRDI QAVATSLLPL TEANLRMFQR AQDD Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.

Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137, PubMed:27974568). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). [UniProt].

Specifications

• Antigen: C19orf66
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: SHFL
• Gene Alias: C19orf66; chromosome 19 open reading frame 66; FLJ11286; Interferon-regulated antiviral protein; IRAV; Repressor of yield of Dengue virus; repressor of yield of DENV; repressor of yield of DENV protein; RYDEN; SFL; SHFL; Shiftless antiviral inhibitor of ribosomal frameshifting protein; UPF0515 protein C19orf66
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55337
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9NUL5
• Gene Symbols: SHFL
• Immunogen: Recombinant protein corresponding to Human C19orf66. Recombinant protein control fragment (Product #RP-99101).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov