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Invitrogen™ INAVA Monoclonal Antibody (OTI6A6)
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Catalog No. PIMA526848
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100 μL
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PIMA526848 100 μL
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Catalog No. PIMA526848 Supplier Invitrogen™ Supplier No. MA526848
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Description

Mouse Monoclonal Antibody

INAVA Monoclonal Antibody for Western Blot, IHC (P)

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen INAVA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI6A6
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene C1orf106
Gene Accession No. Q3KP66
Gene Alias 1700034M08Rik; 4933426C09Rik; 5730559C18Rik; AI586180; C1orf106; chromosome 1 open reading frame 106; D1Mgi54; Inava; Innate immunity activator protein; RGD1311892; RIKEN cDNA 5730559C18 gene; similar to hypothetical protein FLJ10901; uncharacterized protein C1orf106; uncharacterized protein C1orf106 homolog
Gene Symbols C1orf106
Host Species Mouse
Immunogen Human recombinant protein fragment corresponding to amino acids 1-270 of C1ORF106 produced in E.coli.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55765
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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