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C1orf106 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 215061AP

Catalog No. 50-173-3454


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Description

Description

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Specifications

Specifications

C1orf106
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Q3KP66, Q7TN12
C1orf106
Rabbit
IgG
150 μL
-20°C
Primary
289399, 55765, 67313
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
C1orf106
Liquid
C1orf106, Inava
C1orf106 Fusion Protein Ag15987
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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