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C1orf106 Mouse anti-Human, Clone: OTI6A6, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526848

Catalog No. PIMA526848


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Description

Description

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
Specifications

Specifications

C1orf106
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q3KP66
C1orf106
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55765
Immunohistochemistry (Paraffin), Western Blot
OTI6A6
Unconjugated
C1ORF106
Liquid
C1ORF106
Human recombit protein fragment corresponding to amino acids 1-270 of C1ORF106 produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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