Invitrogen™ INAVA Monoclonal Antibody (OTI6A6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA526848

Catalog No. PIMA526848

Description

INAVA Monoclonal Antibody for Western Blot, IHC (P)

Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (PubMed:28436939). In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation (PubMed:29420262). [UniProt].

Specifications

• Antigen: INAVA
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q3KP66
• Gene Symbols: C1orf106
• Immunogen: Human recombinant protein fragment corresponding to amino acids 1-270 of C1ORF106 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI6A6
• Conjugate: Unconjugated
• Gene: C1orf106
• Gene Alias: 1700034M08Rik; 4933426C09Rik; 5730559C18Rik; AI586180; C1orf106; chromosome 1 open reading frame 106; D1Mgi54; Inava; Innate immunity activator protein; RGD1311892; RIKEN cDNA 5730559C18 gene; similar to hypothetical protein FLJ10901; uncharacterized protein C1orf106; uncharacterized protein C1orf106 homolog
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55765
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid