C1orf124 Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-3365	100 μL

Catalog No. 50-198-3365 Supplier Bioss Supplier No. BS15013R

Description

Rabbit Polyclonal Antibody

SPRTN is a regulator of UV-induced DNA damage response: acts as a ′reader′ of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. SPRTN is recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. It facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. It is also required for localization of DNA polymerase eta (POLH) to sites of UV damage.

Specifications

• Antigen: C1orf124
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: SPRTN
• Gene Accession No.: Q9H040
• Gene Alias: C1orf124; DDDL1880; dJ876B10.3; DNA damage protein targeting VCP; DNA damage-targeting VCP (p97) adaptor; DVC1; PRO4323; Protein with SprT-like domain at the N terminus; Spartan; SprT-like domain-containing protein Spartan; SprT-like N-terminal domain; SPRTN; UNQ1880/PRO4323; zinc finger RAD18 domain-containing protein
• Gene Symbols: SPRTN
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human C1orf124.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 83932
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG