Invitrogen™ C1orf21 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA555432

Catalog No. PIPA555432

Description

Immunogen sequence: AKHVATVQNE EEAQKGKNYQ NGDVFGDEYR IKPVEEVKYM KNGAEEEQKI AARNQENLEK SASSNVRLKT NKEVPGLVHQ PRANMHISES QQEFFRMLDE KIEKGRDYCS EE Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.

Specifications

• Antigen: C1orf21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C1orf21
• Gene Alias: C1orf21; Cell proliferation-inducing gene 13 protein; chromosome 1 open reading frame 21; PIG13; proliferation-inducing protein 13; uncharacterized protein C1orf21
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81563
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9H246
• Gene Symbols: C1orf21
• Immunogen: Recombinant protein corresponding to Human C1orf21. Recombinant protein control fragment (Product #RP-89715).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov