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Invitrogen™ C1orf51 Polyclonal Antibody
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Catalog No. PIPA5111391
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100 μL
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PIPA5111391 100 μL
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Catalog No. PIPA5111391 Supplier Invitrogen™ Supplier No. PA5111391
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SLGGGKHQLT KHFPSHHSDS AASSPASPME KMDQTQLGHL ALKPKQPWHL TQWPAMNLTW IHTTPICNPP LSSPGTISFS HGPLGTGTGI Highest antigen sequence indentity to the following orthologs: Rat - 74%, Mouse - 72%.

Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen C1orf51
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.30 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Ciart
Gene Accession No. Q8N365
Gene Alias C1orf51; C5H1orf51; ChIP-derived repressor of network oscillator; CHRONO; Ciart; circadian associated repressor of transcription; circadian-associated transcriptional repressor; Computationally highlighted repressor of the network oscillator; GM129; hypothetical gene supported by NM_017187; RGD1566380
Gene Symbols Ciart
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human C1orf51. Recombinant protein control fragment (Product #RP-106532).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 148523
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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