Invitrogen™ C1orf57 Polyclonal Antibody

Catalog No.	Quantity
PIPA521930	100 μL

Catalog No. PIPA521930 Supplier Invitrogen™ Supplier No. PA521930

Description

Rabbit Polyclonal Antibody

Recommended positive controls: Molt-4. Predicted reactivity: Rhesus Monkey (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190 amino acid proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP. Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency. The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Specifications

• Antigen: C1orf57
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.83 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene: Ntpcr
• Gene Accession No.: Q9BSD7
• Gene Alias: 2310079N02Rik; AI449709; C1orf57; cancer-related nucleoside-triphosphatase; Cancer-related nucleoside-triphosphatase homolog; CH1073-266P11.1; HCR-NTPase; NTPase; Ntpcr; Nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog; nucleoside-triphosphatase, cancer-related; RGD1306192; RP4-659I19.2; RP4-678E16.2; zgc:92420
• Gene Symbols: Ntpcr
• Host Species: Rabbit
• Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human C1orf57. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 84284
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov