Invitrogen™ C1orf57 Polyclonal Antibody

Catalog No.	Quantity
PIPA590139	100 μL

Catalog No. PIPA590139 Supplier Invitrogen™ Supplier No. PA590139

Description

Rabbit Polyclonal Antibody

Immunogen sequence: LALPVLRNAD CSSGPGQRVC VIDEIGKMEL FSQLFIQAVR QTLSTPGTII LGTIPVPKGK PLALVEEIRN RKDVKVFNVT KENRNHLLPD IVTCVQSSRK; Positive Samples: U-251MG, A-431, 293T.

Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190 amino acid proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP. Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency. The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Specifications

• Antigen: C1orf57
• Applications: ELISA, Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 2.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: Ntpcr
• Gene Accession No.: Q9BSD7, Q9CQA9
• Gene Alias: 2310079N02Rik; AI449709; C1orf57; cancer-related nucleoside-triphosphatase; Cancer-related nucleoside-triphosphatase homolog; CH1073-266P11.1; HCR-NTPase; NTPase; Ntpcr; Nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog; nucleoside-triphosphatase, cancer-related; RGD1306192; RP4-659I19.2; RP4-678E16.2; zgc:92420
• Gene Symbols: Ntpcr
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 91-190 of human NTPCR (NP_1157001).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 66566, 84284
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG