Invitrogen™ C1orf74 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531680

Catalog No. PIPA531680

Description

Recommended positive controls: U87-MG. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

C1orf74, also known as URCL4, is located on chromosome 1q32.2 and encodes a previously uncharacterized protein. Recent studies have revealed that C1orf74 is significantly up-regulated in various cancers, including cervical cancer and lung adenocarcinoma. The overexpression of C1orf74 is associated with poor prognosis, indicating its potential role in tumor progression and proliferation. Mechanistically, C1orf74 has been shown to positively regulate the EGFR/AKT/mTORC1 signaling pathway, which is crucial for cell growth and survival. Knockdown studies have demonstrated that reducing C1orf74 expression inhibits cancer cell growth, highlighting it as a potential therapeutic target. Additionally, C1orf74's role in immune cell infiltration suggests it may influence the tumor immune microenvironment, further implicating its importance in cancer biology.

Specifications

• Antigen: C1orf74
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C1orf74
• Gene Alias: C1orf74; chromosome 1 open reading frame 74; UPF0739 protein C1orf74; up-regulated in lung cancer 4; URLC4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 148304
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q96LT6
• Gene Symbols: C1orf74
• Immunogen: Recombinant protein encompassing a sequence within the center region of human C1orf74. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG